Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila.

@article{KulaEversole2010SurprisingGE,
  title={Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila.},
  author={Elżbieta Kula-Eversole and Emi Nagoshi and Yuhua Shang and Joseph M. Tortes i Rodriguez and Ravi Allada and Michael Rosbash},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 30},
  pages={13497-502}
}
To compare circadian gene expression within highly discrete neuronal populations, we separately purified and characterized two adjacent but distinct groups of Drosophila adult circadian neurons: the 8 small and 10 large PDF-expressing ventral lateral neurons (s-LNvs and l-LNvs, respectively). The s-LNvs are the principal circadian pacemaker cells, whereas recent evidence indicates that the l-LNvs are involved in sleep and light-mediated arousal. Although half of the l-LNv-enriched mRNA… CONTINUE READING
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