Surgical stress induces brain-derived neurotrophic factor reduction and postoperative cognitive dysfunction via glucocorticoid receptor phosphorylation in aged mice.

Abstract

AIMS This study explored whether surgical stress-induced glucocorticoid receptor (GR) phosphorylation is related to postoperative cognitive dysfunction (POCD) in aged individuals. Inhibition of GR activation could be an effective treatment for POCD. METHODS A laparotomy was given to C57/BL6 mice in POCD group both 20 and 6 months old. Animals in control… (More)
DOI: 10.1111/cns.12368

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