Surgical resection for clinical perineural invasion from cutaneous squamous cell carcinoma of the head and neck.

@article{Panizza2012SurgicalRF,
  title={Surgical resection for clinical perineural invasion from cutaneous squamous cell carcinoma of the head and neck.},
  author={Benedict James Panizza and Clementino Arturo Solares and Michael Redmond and Priya Parmar and P K O'rourke},
  journal={Head & neck},
  year={2012},
  volume={34 11},
  pages={1622-7}
}
BACKGROUND Perineural invasion (PNI) in cutaneous squamous cell carcinoma of the head and neck (SCCHN) is associated with decreased survival. Patients with large nerve or clinical PNI present with clinical signs and symptoms or MRI evidence of cranial nerve involvement. These patients often succumb to disease that spreads into the brainstem. In our experience, when the disease extends up to the Gasserian or Geniculate ganglion, surgical resection with negative margins provides the best chance… CONTINUE READING

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