Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity

@inproceedings{Mulder2016SurgicalRO,
  title={Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity},
  author={Petra Mulder and Martine C Morrison and Peter Y. Wielinga and Wim van Duyvenvoorde and Teake Kooistra and Robert Kleemann},
  booktitle={International Journal of Obesity},
  year={2016}
}
Background:Non-alcoholic fatty liver disease (NAFLD) is strongly associated with abdominal obesity. Growing evidence suggests that inflammation in specific depots of white adipose tissue (WAT) has a key role in NAFLD progression, but experimental evidence for a causal role of WAT is lacking.Methods:A time-course study in C57BL/6J mice was performed to establish which WAT depot is most susceptible to develop inflammation during high-fat diet (HFD)-induced obesity. Crown-like structures (CLS… CONTINUE READING
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