Surgical denervation of ocular sympathetic afferents decreases local transforming growth factor-beta and abolishes immune privilege.

@article{Vega2009SurgicalDO,
  title={Surgical denervation of ocular sympathetic afferents decreases local transforming growth factor-beta and abolishes immune privilege.},
  author={Jose M Lopez Vega and Hiroshi Keino and Sharmila Masli},
  journal={The American journal of pathology},
  year={2009},
  volume={175 3},
  pages={1218-25}
}
Mounting evidence points to a role for the sympathetic nervous system in suppressing inflammation. This role might be of specific relevance for immune privilege in the eye, where, sporadically, patients with denervated sympathetic fibers develop chronic inflammation. The present study used mice to investigate whether the robust innervation of intraocular structures by the sympathetic system plays a role in maintaining ocular immune privilege. We first performed surgical removal of the superior… CONTINUE READING
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