Surgical correction of the craniofacial anomalies in Apert syndrome.

  title={Surgical correction of the craniofacial anomalies in Apert syndrome.},
  author={John Butler Mulliken and R J Bruneteau},
  journal={Clinics in plastic surgery},
  volume={18 2},
The craniofacial anomalies in Apert syndrome are some of the most obvious manifestations of a systemic disorder directed by an abnormal genome (pleiotropy). Although our knowledge of etiopathogenesis is woefully inadequate, imaginative surgical techniques have evolved to correct the major functional and aesthetic problems in this syndrome. During infancy, the frontal (or nasofrontal) skeleton is modeled and advanced in order to protect the proptotic globes and to expand the anterior cranial… CONTINUE READING