Surgical approach for ulcerated locally advanced breast cancer. A single Center experience: a retrospective study.

Abstract

AIM The aim of our retrospective study is to analyze surgical possibilities for the extended LABC in those cases not suitable for a neoadjuvant chemotherapy step and to consider various reconstruction techniques. MATERIAL OF STUDY Between 2009 and 2015 we enrolled 11 patients, admitted to the Emergency Department, presenting ulcerated LABC that needed palliative surgical demolitive procedures because of bleeding and anemia and in which was necessary to use natural tissues transposition or synthetic substitutes for the reconstruction of the skin flaps. RESULTS The mean follow up was 12 months. Mortality rate was 82% (9 patients); in 2 cases there was local relapse after 6 months; 9 months was the longest disease free survival. DISCUSSION Thanks to multidisciplinary strategies LABC's surgical treatment improved results with a five-year survival rate between 30-40% and better quality of survival. Despite extended demolitive approach, there is still a 50% of death because of metastases. CONCLUSIONS Our results confirm that musculocutaneous flap, skin anterior thigh grafts, bilayer matrix wound dressing are excellent reconstructive strategies in locally advanced ulcerated breast cancer after aggressive extended surgery even if palliative to improve patients' further survival. Our data also showed that those patients presenting medium level of malignancy as "luminal b" subtype (7 patients) if treated earlier with a radical surgical procedure would have better prognosis. KEY WORDS Oncoplastic techniques, Ulcerated breast cancer.

Cite this paper

@article{Laforgia2017SurgicalAF, title={Surgical approach for ulcerated locally advanced breast cancer. A single Center experience: a retrospective study.}, author={Rita Laforgia and Clelia Punzo and Annunziata Panebianco and Annalisa Volpi and Marina Minafra and Maria Grazia Sederino}, journal={Annali italiani di chirurgia}, year={2017}, volume={88} }