Surgical adjuvant chemotherapy: results with one short course with cyclophosphamide after mastectomy for breast cancer.

@article{NissenMeyer1978SurgicalAC,
  title={Surgical adjuvant chemotherapy: results with one short course with cyclophosphamide after mastectomy for breast cancer.},
  author={R Nissen-Meyer and K Kjellgren and K Malmio and Bengt M{\aa}nsson and Torbjarn Norin},
  journal={Cancer},
  year={1978},
  volume={41 6},
  pages={2088-98}
}
One single six-day course with cyclophosphamide (total dose 30 mg/kg) was given immediately after mastectomy to 507 breast cancer patients, with 519 randomized controls receiving no adjuvant chemotherapy. The control group now has 234 recurrences and 196 deaths, and the treatment group 175 recurrences and 146 deaths. The differences of 59 recurrences and 50 deaths in favour of the treatment group are significant with p values less than 0.001 and less than 0.01 respectively. The differences in… CONTINUE READING