Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats.

@article{He2012SurgeryUH,
  title={Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats.},
  author={Hui-juan He and Yi Wang and Yuan Le and Kai-ming Duan and Xue-bin Yan and Qin Liao and Yan Yu Liao and Jian-Bin Tong and Niccol{\`o} Terrando and Wen Min Ouyang},
  journal={CNS neuroscience & therapeutics},
  year={2012},
  volume={18 12},
  pages={
          994-1002
        }
}
AIM Postoperative cognitive dysfunction (POCD) is a growing and largely underestimated problem without defined etiology. Herein, we sought to determine the relationship between cognitive decline, blood-brain barrier (BBB) permeability, and inflammation, namely high mobility group box-1 (HMGB1), after surgery in aged rats. METHODS Aged rats were randomly assigned as surgery group (n = 45, splenectomy under general anesthesia), anesthesia (n = 45, 2% isoflurane for 2 h), and naïve control (n… CONTINUE READING
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