Surgery to cure the Zollinger-Ellison syndrome.

  title={Surgery to cure the Zollinger-Ellison syndrome.},
  author={Jeffrey A. Norton and Douglas L. Fraker and H. Richard Alexander and David J Venzon and John L. Doppman and Javier Serrano and Stephan Goebel and Paolo L. Peghini and Praveen K. Roy and Fathia Gibril and Robert Thomas Jensen},
  journal={The New England journal of medicine},
  volume={341 9},
BACKGROUND AND METHODS The role of surgery in patients with the Zollinger-Ellison syndrome is controversial. To determine the efficacy of surgery in patients with this syndrome, we followed 151 consecutive patients who underwent laparotomy between 1981 and 1998. Of these patients, 123 had sporadic gastrinomas and 28 had multiple endocrine neoplasia type 1 with an imaged tumor of at least 3 cm in diameter. Tumor-localization studies and functional localization studies were performed routinely… CONTINUE READING
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