Surgery following neoadjuvant chemotherapy for HER2-positive locally advanced breast cancer. Time to reconsider the standard attitude.

Abstract

BACKGROUND While the addition of targeted therapy to neoadjuvant chemotherapy (NACT) dramatically increases the rate of pathological complete response in HER2-positive breast cancer, no reduction in the rate of mastectomy has been observed in randomised studies. METHODS A retrospective single centre analysis of all patients treated with anti HER2-based… (More)
DOI: 10.1016/j.ejca.2015.01.063

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