Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth?

@inproceedings{Retsky2010SurgeryTO,
  title={Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth?},
  author={Michael Retsky and Romano Demicheli and William J. M. Hrushesky and Michael Baum and Isaac D. Gukas},
  booktitle={Cancers},
  year={2010}
}
We review our work over the past 14 years that began when we were first confronted with bimodal relapse patterns in two breast cancer databases from different countries. These data were unexplainable with the accepted continuous tumor growth paradigm. To explain these data, we proposed that metastatic breast cancer growth commonly includes periods of temporary dormancy at both the single cell phase and the avascular micrometastasis phase. We also suggested that surgery to remove the primary… CONTINUE READING
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