Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine

@inproceedings{Davis2010SurfingAG,
  title={Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine},
  author={Nickolas Allen Davis and James E. Crowe and Nicholas M. Pajewski and Brett A. McKinney},
  booktitle={Genes and Immunity},
  year={2010}
}
The variation in antibody response to vaccination likely involves small contributions of numerous genetic variants, such as single-nucleotide polymorphisms (SNPs), which interact in gene networks and pathways. To accumulate the bits of genetic information relevant to the phenotype that are distributed throughout the interaction network, we develop a network eigenvector centrality algorithm (SNPrank) that is sensitive to the weak main effects, gene–gene interactions and small higher-order… CONTINUE READING
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Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination

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