Surfactin C inhibits platelet aggregation

@article{Kim2006SurfactinCI,
  title={Surfactin C inhibits platelet aggregation},
  author={Sung Dae Kim and S. Park and J. Cho and H. Park and J. Lim and H. I. Yun and S. C. Park and K. Lee and S. Kim and M. Rhee},
  journal={Journal of Pharmacy and Pharmacology},
  year={2006},
  volume={58}
}
  • Sung Dae Kim, S. Park, +7 authors M. Rhee
  • Published 2006
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
  • This study was designed to investigate the effect of surfactin C, which is derived from Bacillus subtilis, on platelet aggregation and homotypic leucocyte aggregation. Surfactin C strongly and dose‐dependently inhibited platelet aggregation, which was stimulated both by thrombin (0.1 U mL−1), a potent agonist that activates the G protein‐coupled protease receptor, and by collagen (5 μg mL−1), a potent ligand that activates αIIbβ3 with IC50 values (concentration inhibiting platelet aggregation… CONTINUE READING
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