Surfactin C inhibits platelet aggregation

  title={Surfactin C inhibits platelet aggregation},
  author={Sung Dae Kim and S. Park and J. Cho and H. Park and J. Lim and H. I. Yun and S. C. Park and K. Lee and S. Kim and M. Rhee},
  journal={Journal of Pharmacy and Pharmacology},
  • Sung Dae Kim, S. Park, +7 authors M. Rhee
  • Published 2006
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
  • This study was designed to investigate the effect of surfactin C, which is derived from Bacillus subtilis, on platelet aggregation and homotypic leucocyte aggregation. Surfactin C strongly and dose‐dependently inhibited platelet aggregation, which was stimulated both by thrombin (0.1 U mL−1), a potent agonist that activates the G protein‐coupled protease receptor, and by collagen (5 μg mL−1), a potent ligand that activates αIIbβ3 with IC50 values (concentration inhibiting platelet aggregation… CONTINUE READING
    25 Citations
    Surfactin inhibits immunostimulatory function of macrophages through blocking NK-kappaB, MAPK and Akt pathway.
    • S. Park, Y. Kim
    • Biology, Medicine
    • International immunopharmacology
    • 2009
    • 34
    Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses.
    • 39


    Suppression of inflammatory responses by surfactin, a selective inhibitor of platelet cytosolic phospholipase A2.
    • 87
    Phospholipase A2: its role in ADP- and thrombin-induced platelet activation mechanisms.
    • R. Puri
    • Chemistry, Medicine
    • The international journal of biochemistry & cell biology
    • 1998
    • 39
    • Highly Influential
    Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane A2 in human platelet aggregation.
    • 46
    Enhancement of plasminogen activation by surfactin C: augmentation of fibrinolysis in vitro and in vivo.
    • 59
    Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells.
    • 44
    • PDF
    Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions.
    • 62
    Surfactin C inhibits the Lipopolysaccharide-induced Transcription of Interleukin-1β and Inducible Nitric Oxide Synthase and Nitric Oxide Production in Murine RAW 264.7 Cells
    • 22
    • Highly Influential
    Activation of the platelet collagen receptor integrin alpha(2)beta(1): its mechanism and participation in the physiological functions of platelets.
    • 31
    Nature and properties of a cytolytic agent produced by Bacillus subtilis.
    • 195
    • PDF