Surfactant replacement attenuates the increase in alveolar permeability in hyperoxia.

@article{Engstrom1989SurfactantRA,
  title={Surfactant replacement attenuates the increase in alveolar permeability in hyperoxia.},
  author={P C Engstrom and Bruce A. Holm and Sadis Matalon},
  journal={Journal of applied physiology},
  year={1989},
  volume={67 2},
  pages={
          688-93
        }
}
Rabbits exposed to hyperoxia develop surfactant deficiency, abnormal lung mechanics, and increased permeability to solute. We investigated whether replenishment of depleted alveolar surfactant by the intratracheal instillation of calf lung surfactant extract (CLSE) would mitigate the increase in alveolar permeability to solute. Twenty-eight rabbits were exposed to 100% O2 for 72 h and received intratracheal instillations of 125 mg CLSE (approximately 170 mumol dipalmitoyl phosphatidylcholine… Expand
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