Surfactant replacement attenuates the increase in alveolar permeability in hyperoxia.

  title={Surfactant replacement attenuates the increase in alveolar permeability in hyperoxia.},
  author={P C Engstrom and Bruce A. Holm and Sadis Matalon},
  journal={Journal of applied physiology},
  volume={67 2},
Rabbits exposed to hyperoxia develop surfactant deficiency, abnormal lung mechanics, and increased permeability to solute. We investigated whether replenishment of depleted alveolar surfactant by the intratracheal instillation of calf lung surfactant extract (CLSE) would mitigate the increase in alveolar permeability to solute. Twenty-eight rabbits were exposed to 100% O2 for 72 h and received intratracheal instillations of 125 mg CLSE (approximately 170 mumol dipalmitoyl phosphatidylcholine… Expand
Hyperoxia-induced alterations of rat alveolar lavage composition and properties.
Measurements of surface properties with the Wilhelmy balance indicate that the ability of the lavage materials to reduce surface tension is impaired following hyperoxia, which means that lethal exposures of rats to oxygen lead to increased amounts of surfactant on the alveolar surface, but the surface properties of the Surfactant are impaired. Expand
Exogenous surfactant rapidly increases PaO2 in mature rabbits with lungs that contain large amounts of saline.
These studies show that the increase in PaO2 after surfactant administration to mature lungs containing large amounts of saline is similar to the increase seen when Surfactant is given to premature infants with RDS. Expand
Mechanisms and Modifications of Hyperoxic Injury to the Mammalian Pulmonary Surfactant System
Oxygen is an indispensable therapeutic agent used extensively in clinical medicine for the mitigation of arterial hypoxemia in patients with a variety of pulmonary and cardiac diseases, but its usefulness is limited by its well-documented toxicity to the central nervous and pulmonary systems. Expand
Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia.
It is reported that newborn rats, which can adapt to even higher levels of hyperoxia than do adult rats, manifest changes in the lung surfactant proteins (SP), especially SP-A and SP-D, which are upregulated at both the pretranslational and post-translational levels in distal lung epithelium in the newborn rat. Expand
Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia.
Iso restored the lung's ability to clear edema after hyperoxic lung injury, probably by stimulation of the recruitment of ion-transporting proteins from intracellular pools to the plasma membrane in rat alveolar epithelium. Expand
Hyperoxia exacerbates microvascular lung injury following acid aspiration.
Intrapulmonary instillation of acid increased PI, HI, and decreased static lung compliance compared to uninjured control animals, and hyperoxia increases acid aspiration-induced inflammatory microvascular lung injury. Expand
Brief 95% O2 exposure effects on surfactant protein and mRNA in rat alveolar and bronchiolar epithelium.
Sharp declines in SP expression occurred by 12 h of 95% O2 and may affect local alveolar stability. Expand
Exogenous surfactants in a piglet model of acute respiratory distress syndrome.
KL-4-Surfactant may improve pulmonary function, reduce alveolar protein leak, and thus be efficacious in the treatment of ARDS, and is speculated to be more like Survanta in this model. Expand
Sepsis and hyperoxia effects on the pulmonary surfactant system in wild-type and iNOS knockout mice
It is concluded that inducible nitric oxide synthase does not influence the amount of pulmonary surfactant or Surfactant subfractions recovered in lavage after 18 h of sepsis or 48 H of hyperoxia. Expand
Surfactant and the adult respiratory distress syndrome.
With further clinical trials and continued research efforts, exogenous surfactant administration should play a useful role in the future therapeutic approach to patients with ARDS. Expand