Surfactant proteins in pulmonary alveolar proteinosis in adults.

  title={Surfactant proteins in pulmonary alveolar proteinosis in adults.},
  author={Frank E. Brasch and Jan Birzele and Matthias Ochs and Susan H Guttentag and O. D. Schoch and Annette Boehler and Michael F. Beers and K. M. Mueller and Samuel B Hawgood and Georg Johnen},
  journal={The European respiratory journal},
  volume={24 3},
Pulmonary alveolar proteinosis (PAP) is a rare disorder characterised histologically by an intra-alveolar accumulation of fine granular eosinophilic and periodic acid-Schiff positive material. In a retrospective study, the composition of the intra-alveolarly accumulated material of adult patients with PAP was analysed by means of immunohistochemistry and Western blotting. In patients with PAP, the current authors found an intra-alveolar accumulation of surfactant protein (SP)-A, precursors of… CONTINUE READING


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