Surfactant proteins SP-A and SP-D in human health and disease.

  title={Surfactant proteins SP-A and SP-D in human health and disease.},
  author={Uday Kishore and Andr{\'e}s L{\'o}pez Bernal and Mohammed F. Kamran and Shweta Saxena and Mamta Singh and Puranam Usha Sarma and Taruna Madan and Trinad Chakraborty},
  journal={Archivum immunologiae et therapiae experimentalis},
  volume={53 5},
Surfactant proteins A (SP-A) and D (SP-D) are lung surfactant-associated hydrophilic proteins that have been implicated in surfactant homeostasis and pulmonary innate immunity. They are collagen-containing C-type (calcium-dependent) lectins, called collectins, and are structurally similar to mannose-binding protein of the lectin pathway of the complement system. Being carbohydrate pattern-recognition molecules, they recognize a broad spectrum of pathogens and allergens via the lectin domain… CONTINUE READING
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