Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha.

@article{Janssen2008SurfactantPA,
  title={Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha.},
  author={William J Janssen and Kathleen A. McPhillips and Matthew G Dickinson and Derek J. Linderman and Konosuke Morimoto and Yi Xiao and Kelly M Oldham and R. William Vandivier and Peter M Henson and Shyra J. Gardai},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 2},
  pages={158-67}
}
RATIONALE Efficient removal of apoptotic cells is essential for the resolution of acute pulmonary inflammation. Alveolar macrophages ingest apoptotic cells less avidly than other professional phagocytes at rest but overcome this defect during acute inflammation. Surfactant protein (SP)-A and SP-D are potent modulators of macrophage function and may suppress clearance of apoptotic cells through activation of the transmembrane receptor signal inhibitory regulatory protein alpha (SIRP alpha… CONTINUE READING
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