Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability.

@article{Wu2003SurfactantPA,
  title={Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability.},
  author={Huixing Wu and Alexander Kuzmenko and Sijue Wan and Lyndsay Schaffer and Alison E Weiss and James H. Fisher and Kwang Sik Kim and Francis X McCormack},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 10},
  pages={1589-602}
}
The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of lung pathogens. In this study, we examined the effect of SP-A and SP-D on the growth and viability of Gram-negative bacteria. The pulmonary clearance of Escherichia coli K12 was… CONTINUE READING