Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways.

@article{Yoshida2001SurfactantPD,
  title={Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways.},
  author={Mitsuhiro Yoshida and Thomas R. Korfhagen and Jeffrey A. Whitsett},
  journal={Journal of immunology},
  year={2001},
  volume={166 12},
  pages={7514-9}
}
Targeted ablation of the surfactant protein D (SP-D) gene caused progressive pulmonary emphysema associated with pulmonary infiltration by foamy alveolar macrophages (AMs), increased hydrogen peroxide production, and matrix metalloproteinase (MMP)-2, -9, and -12 expression. In the present study, the mechanisms by which SP-D influences macrophage MMP activity were assessed in AMs from SP-D(-/-) mice. Tissue lipid peroxides and reactive carbonyls were increased in lungs of SP-D(-/-) mice… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 73 extracted citations

GM-CSF mediates alveolar epithelial type II cell changes, but not emphysema-like pathology, in SP-D-deficient mice.

American journal of physiology. Lung cellular and molecular physiology • 2004
View 8 Excerpts
Highly Influenced

Collectins in urinary tract and kidney diseases

International Urology and Nephrology • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…