Surfactant protein D gene regulation. Interactions among the conserved CCAAT/enhancer-binding protein elements.

@article{He2002SurfactantPD,
  title={Surfactant protein D gene regulation. Interactions among the conserved CCAAT/enhancer-binding protein elements.},
  author={Yanchun He and Erika Crouch},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 22},
  pages={19530-7}
}
Surfactant protein D (SP-D) plays roles in pulmonary host defense and surfactant homeostasis and is increased following acute lung injury. Given the importance of CCAAT/enhancer-binding protein (C/EBP)-binding elements in the systemic acute-phase response and lung development and the expression of C/EBP isoforms by lung epithelial cells, we hypothesized that conserved C/EBP motifs in the near-distal and proximal promoters contribute to the regulation of SP-D expression by C/EBPs. Five SP-D… CONTINUE READING

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