Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication.

@article{Meschi2005SurfactantPD,
  title={Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication.},
  author={Joseph Meschi and Erika C. Crouch and Paul R. Skolnik and Khabirah Yahya and Uffe Holmskov and Rikke Leth-Larsen and Ida Tornoe and Tesfaldet Tecle and Mitchell R. White and Kevan L Hartshorn},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 11},
  pages={3097-107}
}
The envelope protein (gp120) of human immunodeficiency virus (HIV) contains highly conserved mannosylated oligosaccharides. These glycoconjugates contribute to resistance to antibody neutralization, and binding to cell surface lectins on macrophages and dendritic cells. Mannose-binding lectin (MBL) binds to gp120 and plays a role in defence against the virus. In this study it is demonstrated that surfactant protein D (SP-D) binds to gp120 and inhibits HIV infectivity at significantly lower… CONTINUE READING

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Interactions of influenza A virus with sialic acids present on porcine surfactant protein D.

American journal of respiratory cell and molecular biology • 2004
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