Surfactant protein C: hormonal control of SP-C mRNA levels in vitro.

@article{Veletza1992SurfactantPC,
  title={Surfactant protein C: hormonal control of SP-C mRNA levels in vitro.},
  author={S V Veletza and Khanh Nichols and Ian Gross and Helen W. -Z. Lu and Diane W. Dynia and Joanna Floros},
  journal={The American journal of physiology},
  year={1992},
  volume={262 6 Pt 1},
  pages={L684-7}
}
We have studied hormonal regulation of the surfactant protein C (SP-C) in fetal 18-dah rat lung explants. SP-C mRNA was detected in Northern blots with a specific rat SP-C cDNA probe and quantified by densitometry. Treatment of the explants with dexamethasone resulted in a dose-dependent increase of the SP-C mRNA level. Transcriptional assays have shown that the regulation of SP-C mRNA by dexamethasone involves a transcriptional step. Administration of the cAMP analogues, 8-bromoadenosine 3',5… CONTINUE READING