Surfactant protein B and C analogues.

@article{Walther2000SurfactantPB,
  title={Surfactant protein B and C analogues.},
  author={Frans J. Walther and Larry M. Gordon and Joseph A. Zasadzinski and Mark A. Sherman and Alan J. Waring},
  journal={Molecular genetics and metabolism},
  year={2000},
  volume={71 1-2},
  pages={
          342-51
        }
}
Mammalian lung surfactant is a mixture of phospholipids and four surfactant-associated proteins (SP-A, SP-B, SP-C, and SP-D). Its major function is to reduce surface tension at the air-water interface in the terminal airways by the formation of a surface-active film highly enriched in dipalmitoyl phosphatidylcholine (DPPC), thereby preventing alveolar collapse during expiration. SP-A and SP-D are large hydrophilic proteins, which play an important role in host defense, whereas the small… 
View on PubMed
chemengr.ucsb.edu
42 Citations
Background Citations
10
Methods Citations
2
Results Citations
1

Figures from this paper

42 Citations

Citation Type

Citation Type

Hydrophobic Surfactant Proteins and Their Analogues
TLDR
Recent research developments with peptide analogues of SP-B and SP-C, designed using either the known primary sequence and three-dimensional (3D) structure of the native proteins or, alternatively, the known 3D structures of closely homologous proteins are reviewed.
COMPARISON OF THREE LIPID FORMULATIONS FOR SYNTHETIC SURFACTANT WITH A SURFACTANT PROTEIN B ANALOG
TLDR
The authors investigated the optimum lipid composition for SP-B1–25 by comparing the effects of natural lung lavage lipids (NLL), a synthetic equivalent of NLL (synthetic lavagelipids SLL), and a standard lipid mixture (TL) on the activities of SP- B1-25.
A sulfur-free peptide mimic of surfactant protein B (B-YL) exhibits high in vitro and in vivo surface activities
TLDR
‘Sulfur-free’ B-YL forms an amphipathic helix-hairpin in surfactant liposomes with high surface activity and is functionally similar to SMB and native SP-B, which provides an extra edge over SMB in the treatment of respiratory failure in preterm infants with RDS.
Surfactant with SP-B and SP-C Analogues Improves Lung Function in Surfactant-Deficient Rats
TLDR
Improvements in oxygenation and lung volume in lavaged rats are dependent on the concentration of dSP-B1–25 in the surfactant preparation and that the presence of SP-Cfc has a relative minor effect on these parameters.
DIMERIC SURFACTANT PROTEIN B PEPTIDE SP-B 1-25 IN NEONATAL AND ACUTE RESPIRATORY DISTRESS SYNDROME
TLDR
The data suggest that dSP-B 1-25 is more efficient in restoring lung function in neonatal RDS and ARDS than mSP- B 1- 25 surfactant.
Lipid polymorphism induced by surfactant peptide SP-B(1-25).
New Synthetic Surfactants – Basic Science
TLDR
The lipid composition seems to be important, as well as a high lipid concentration in the suspension, for successful treatment of many respiratory diseases, it is also desirable that the synthetic surfactant resists inactivation by plasma components leaking into the alveoli.
An oxidation-resistant peptide mimic of surfactant protein B (B-YL) forms an amphipathic helix-hairpin in liposomes with high surface activity
TLDR
B-YL’s resistance against free oxygen radical damage provides an extra edge over oxidized SMB in the treatment of respiratory failure in preterm infants with RDS and children and adults with acute lung injury.
Comprehensive characterization and proteoform analysis of the hydrophobic surfactant proteins B and C in calf pulmonary surfactant.
Composition, Structure and Biophysical Functions of Pulmonary Surfactants: Their Deficiency and Strategy for Remedy
Pulmonary surfactant (PS) is a complex mixture of lipids and proteins that forms a monomolecular film at the lung-air interface. It serves dual purposes: (i) lowers the surface tension; and (ii)…
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 76 REFERENCES
Pulmonary surfactant protein B (SP-B): structure-function relationships.
TLDR
These data, together with findings that the SP-B-related peptides increase inter- and intramolecular order of the phospholipid layer, suggest thatSP-B resists surface tension by increasing lateral stability of the phosphate layer.
Full length synthetic surfactant proteins, SP-B and SP-C, reduce surfactant inactivation by serum.
Pulmonary surfactant protein B: a structural model and a functional analogue.
Biophysical activity of an artificial surfactant containing an analogue of surfactant protein (SP)-C and native SP-B.
TLDR
AnSP-C analogue is synthesized, named SP-C(LKS), which differs from SP- C mainly by the exchange of most of the Val residues in positions 16-28 with Leu residues to promote an alpha-helical conformation, and by the introduction of Lys residues at positions 17, 22 and 27 in order to locate positive charges around the helical circumference and thereby avoid self polymerization.
Structure and properties of surfactant protein B.
Synthetic mimics of surfactant proteins B and C: in vitro surface activity and effects on lung compliance in two animal models of surfactant deficiency.
TLDR
In vitro functional determinations of synthetic surfactant peptides are instrumental in the preparation of replacement surfactants, and that dispersions thus selected represent viable therapeutic alternatives to current treatments for respiratory distress syndrome.
A function of lung surfactant protein SP-B.
TLDR
The effect of SP-B1-25 on fatty acid isotherms is remarkably similar to that of simple poly-cations, suggesting that such polymers might be useful as components of replacement surfactants for the treatment of respiratory distress syndrome.
Lipid mixing is mediated by the hydrophobic surfactant protein SP-B but not by SP-C.
Dimeric N-terminal segment of human surfactant protein B (dSP-B(1-25)) has enhanced surface properties compared to monomeric SP-B(1-25).
Characterization of lipid insertion into monomolecular layers mediated by lung surfactant proteins SP-B and SP-C.
TLDR
The results of this study suggest that the surface properties and the hydrophobic nature of SP-B and SP-C are important for the protein-mediated monolayer formation.
...
1
2
3
4
5
...