Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity.

@article{Ledford2010SurfactantPI,
  title={Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity.},
  author={Julie Gunnells Ledford and Bernice Lo and Mich{\`e}le M. Kislan and Joseph M. Thomas and Katherine E. Evans and Derek W. Cain and Monica Kraft and Kristi L. Williams and Jo Rae Wright},
  journal={Journal of immunology},
  year={2010},
  volume={185 7},
  pages={3884-94}
}
During pulmonary infections, a careful balance between activation of protective host defense mechanisms and potentially injurious inflammatory processes must be maintained. Surfactant protein A (SP-A) is an immune modulator that increases pathogen uptake and clearance by phagocytes while minimizing lung inflammation by limiting dendritic cell (DC) and T cell activation. Recent publications have shown that SP-A binds to and is bacteriostatic for Mycoplasma pneumoniae in vitro. In vivo, SP-A aids… CONTINUE READING