Surfactant-associated protein inhibits phospholipid secretion from type II cells.

@article{Rice1987SurfactantassociatedPI,
  title={Surfactant-associated protein inhibits phospholipid secretion from type II cells.},
  author={William L. R. Rice and Gary F. Ross and Fannie M Singleton and Sharon L. Dingle and Jeffrey A. Whitsett},
  journal={Journal of applied physiology},
  year={1987},
  volume={63 2},
  pages={
          692-8
        }
}
Secretion of [3H]phosphatidylcholine ([3H]PC) from isolated rat pulmonary type II epithelial cells was inhibited by the surfactant-associated protein of Mr = 35,000 (SAP-35) purified from canine lung surfactant. SAP-35 inhibited [3H]PC secretion in a dose-dependent manner and significantly inhibited basal, phorbol ester, beta-adrenergic, and P2-purinergic agonist-induced [3H]PC secretion. SAP-35 significantly inhibited [3H]PC secretion from 1 to 3 h after treatment. The IC50 for inhibition of… CONTINUE READING
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