Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.

@article{Borron2000SurfactantassociatedPA,
  title={Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.},
  author={Paul J. Borron and J Clarke McIntosh and Thomas R. Korfhagen and Jeffrey A. Whitsett and Jeremy Taylor and Jo Rae Wright},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={278 4},
  pages={L840-7}
}
The role of surfactant-associated protein (SP) A in the mediation of pulmonary responses to bacterial lipopolysaccharide (LPS) was assessed in vivo with SP-A gene-targeted [SP-deficient; SP-A(-/-)] and wild-type [SP-A(+/+)] mice. Concentrations of tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein-2, and nitric oxide were determined in recovered bronchoalveolar lavage fluid after intratracheal administration of LPS. SP-A(-/-) mice produced significantly more TNF-alpha and nitric… CONTINUE READING

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