Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure.

@article{Mulrooney2005SurfactantAP,
  title={Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure.},
  author={Neil P. Mulrooney and Zahra J Champion and Timothy J. M. Moss and Ilias Nitsos and Machiko Ikegami and Alan Hall Jobe},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={171 5},
  pages={488-93}
}
Although continuous positive airway pressure (CPAP) is used frequently for preterm infants, the relationships between the amount of surfactant and lung physiologic and injury responses to CPAP are unknown. Therefore, saturated phosphatidylcholine (Sat PC) was measured to quantify the surfactant necessary for preterm lambs to breathe successfully on a CPAP of 5 cm H(2)O (CPAP 5). Five of 21 lambs delivered at 130-136 days gestation failed to keep PCO(2) below 100 mm Hg by 2 hours. The lambs that… CONTINUE READING