Surfactant abnormalities and adult respiratory failure

  title={Surfactant abnormalities and adult respiratory failure},
  author={Werner Seeger and Ulrich Pison and Reiner Buchhorn and U. Obertacke and Th. Joka},
Surfactant abnormalities have been implicated in the development of the acute respiratory distress syndrome in adults. Experimental studies show that surfactant inhibition by protein-leak into the alveolar space is of major importance under these circumstances. Fibrin(ogen)-surfactant-interaction appears to contribute to disturbances of surfactant function with subsequent alveolar instability and ventilation-perfusion-mismatch. In a prospective study in severely injured patients, the surfactant… CONTINUE READING


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Surfactant abnormalities in patients with respiratory failure following multiple trauma

  • U Pison, W Seeger, +5 authors K-P SchmitNeuerburg
  • Am Rev Respir Dis
  • 1989
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