Surfactant Protein-A Suppresses Eosinophil-Mediated Killing of Mycoplasma pneumoniae in Allergic Lungs

@inproceedings{Ledford2012SurfactantPS,
  title={Surfactant Protein-A Suppresses Eosinophil-Mediated Killing of Mycoplasma pneumoniae in Allergic Lungs},
  author={Julie Gunnells Ledford and Sambuddho Mukherjee and Mich{\`e}le M. Kislan and Julia L. Nugent and John W. Hollingsworth and Jo Rae Wright},
  booktitle={PloS one},
  year={2012}
}
Surfactant protein-A (SP-A) has well-established functions in reducing bacterial and viral infections but its role in chronic lung diseases such as asthma is unclear. Mycoplasma pneumoniae (Mp) frequently colonizes the airways of chronic asthmatics and is thought to contribute to exacerbations of asthma. Our lab has previously reported that during Mp infection of non-allergic airways, SP-A aides in maintaining airway homeostasis by inhibiting an overzealous TNF-alpha mediated response and, in… CONTINUE READING