Surface tension influences cell shape and phagocytosis in alveolar macrophages.

@article{Akei2006SurfaceTI,
  title={Surface tension influences cell shape and phagocytosis in alveolar macrophages.},
  author={Hiroko Saito Akei and Jeffrey A. Whitsett and Michelle Buroker and Takafumi Ninomiya and Haruyuki Tatsumi and Timothy E. Weaver and Machiko Ikegami},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 4},
  pages={L572-9}
}
The effect of surface tension on alveolar macrophage shape and phagocytosis was assessed in vivo and in vitro. Surface tension was regulated in vivo by conditionally expressing surfactant protein (SP)-B in Sftpb-/- mice. Increased surface tension and respiratory distress were produced by depletion of SP-B and were readily reversed by repletion of SP-B in vivo. Electron microscopy was used to demonstrate that alveolar macrophages were usually located beneath the surfactant film on the alveolar… CONTINUE READING

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