Surface presentation of bioactive ligands in a nonadhesive background using DOPA-tethered biotinylated poly(ethylene glycol).

@article{Gunawan2007SurfacePO,
  title={Surface presentation of bioactive ligands in a nonadhesive background using DOPA-tethered biotinylated poly(ethylene glycol).},
  author={Rico C Gunawan and James A King and Bruce P. Lee and Philip B Messersmith and William M. Miller},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2007},
  volume={23 21},
  pages={10635-43}
}
We have developed surfaces for the selective presentation of biotinylated peptides and proteins in a background that resists nonspecific protein adsorption; controlled amounts of biotinylated poly(ethylene glycol) (MW 3400 Da; PEG3400) anchored to titanium-dioxide-coated surfaces via an adhesive tri-peptide sequence of L-3,4-dihydroxyphenylalanine (DOPA3-PEG3400-biotin; DPB) were incorporated within a DOPA3-PEG2000 background. Using optical waveguide lightmode spectroscopy, we found that the… CONTINUE READING
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Mussel Adhesive - Inspired Surface Modification for the Preparation of Nonfouling Materials

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