Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides.

@article{Linman2008SurfacePR,
  title={Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides.},
  author={Matthew J Linman and Joseph D Taylor and Hai Dong Yu and Xi Chen and Quan Cheng},
  journal={Analytical chemistry},
  year={2008},
  volume={80 11},
  pages={4007-13}
}
Lectins are carbohydrate binding proteins found in plants, animals, and microorganisms. They serve as important models for understanding protein-carbohydrate interactions at the molecular level. We report here the fabrication of a novel sensing interface of biotinylated sialosides to probe lectin-carbohydrate interactions using surface plasmon resonance spectroscopy (SPR). The attachment of carbohydrates to the surface using biotin-NeutrAvidin interactions and the implementation of an inert… CONTINUE READING

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