Surface plasmon resonance for rapid screening of uranyl affine proteins.


A sensitive immunoassay based on SPR analysis was developed to measure uranyl cation (UO(2)(2+)) affinity for any protein in a free state under physiological conditions. The technique involves immobilization of a specific monoclonal antibody (mAb) raised against UO(2)(2+) and 1,10-phenanthroline-2,9-dicarboxylic acid (DCP) used as a probe of UO(2)(2… (More)
DOI: 10.1021/ac102578y

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