Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies.

@article{Ramakrishnan2009SurfacePR,
  title={Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies.},
  author={Muthu Ramakrishnan and Karunya K. Kandimalla and T. M. Wengenack and Kyle G. Howell and J. F. Poduslo},
  journal={Biochemistry},
  year={2009},
  volume={48 43},
  pages={10405-15}
}
Several different monoclonal antibodies (mAbs) have been actively developed in the field of Alzheimer's disease (AD) for basic science and clinical applications; however, the binding kinetics of many of the mAbs with the beta-amyloid peptides (Abeta) are poorly understood. A panel of mAbs with different Abeta recognition sites, including our plaque-binding… CONTINUE READING