Surface plasmon resonance as a high throughput method to evaluate specific and non-specific binding of nanotherapeutics.

@article{Schneider2015SurfacePR,
  title={Surface plasmon resonance as a high throughput method to evaluate specific and non-specific binding of nanotherapeutics.},
  author={Craig S Schneider and Adip G. Bhargav and J Gutierrrez Perez and Aniket S. Wadajkar and Jeffrey A Winkles and Graeme F Woodworth and Anthony W Kim},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={219},
  pages={331-344}
}
Surface plasmon resonance (SPR) is a powerful analytical technique used to quantitatively examine the interactions between various biomolecules, such as proteins and nucleic acids. The technique has been particularly useful in screening and evaluating binding affinity of novel small molecule and biomolecule-derived therapeutics for various diseases and applications including lupus medications, thrombin inhibitors, HIV protease inhibitors, DNA gyrase inhibitors and many others. Recently, there… CONTINUE READING