Surface molecules involved in the activation and regulation of T or natural killer lymphocytes in humans.

@article{Moretta1989SurfaceMI,
  title={Surface molecules involved in the activation and regulation of T or natural killer lymphocytes in humans.},
  author={Alessandro Moretta and Ermanno Ciccone and Giuseppe Pantaleo and Giuseppe Tambussi and Cristina Bottino and Giovanni Melioli and Maria Cristina Mingari},
  journal={Immunological reviews},
  year={1989},
  volume={111},
  pages={145-75}
}
The surface molecules that mediate activation of different subsets of T or NK cells have been reviewed. A suitable approach to the study of different lymphocyte activation pathways is provided by mAbs specific for these molecules. MAbs directed to the CD3 surface molecules mediate a polyclonal T-cell activation, whereas mAbs to "clonotypic" structures of TCR only trigger cells bearing the corresponding clonotypic determinant (thus mimicking the effect of antigen/MHC). MAbs directed to… CONTINUE READING

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