Surface-modified amikacin-liposomes: organ distribution and interaction with plasma proteins.

@article{Bucke1998SurfacemodifiedAO,
  title={Surface-modified amikacin-liposomes: organ distribution and interaction with plasma proteins.},
  author={W. Bucke and S. Leitzke and J. Diederichs and K. Borner and H. Hahn and S. Ehlers and R. M{\"u}ller},
  journal={Journal of drug targeting},
  year={1998},
  volume={5 2},
  pages={
          99-108
        }
}
Amikacin-loaded liposomes were produced and surface-modified by adsorption of PEG 4000, Tween 80, poloxamer 407 and gelatin. The organ distribution was studied in mice by analysing the amikacin content in liver, spleen, lung, kidneys and serum. Highest serum levels were obtained with the PEG- and Tween 80 modified liposomes (at 2 hours p.inj.). Modification of the liposomes with gelatin as opsonization promoting agent distinctly increased the amikacin concentration in the liver from 36 to 66 mg… Expand
Important role of serum proteins associated on the surface of particles in their hepatic disposition.
Immunological and Toxicological Considerations for the Design of Liposomes
Pharmacokinetic Consequences of Pegylation
Permeabilisation and solubilisation of soybean phosphatidylcholine bilayer vesicles, as membrane models, by polysorbate, Tween 80.
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