Surface-modified CMOS IC electrochemical sensor array targeting single chromaffin cells for highly parallel amperometry measurements

@article{Huang2017SurfacemodifiedCI,
  title={Surface-modified CMOS IC electrochemical sensor array targeting single chromaffin cells for highly parallel amperometry measurements},
  author={Meng Huang and Joannalyn B. Delacruz and John C. Ruelas and Shailendra S. Rathore and Manfred Lindau},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2017},
  volume={470},
  pages={113-123}
}
Amperometry is a powerful method to record quantal release events from chromaffin cells and is widely used to assess how specific drugs modify quantal size, kinetics of release, and early fusion pore properties. Surface-modified CMOS-based electrochemical sensor arrays allow simultaneous recordings from multiple cells. A reliable, low-cost technique is presented here for efficient targeting of single cells specifically to the electrode sites. An SU-8 microwell structure is patterned on the chip… CONTINUE READING
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