Surface modifications of influenza proteins upon virus inactivation by β-propiolactone*

  title={Surface modifications of influenza proteins upon virus inactivation by β-propiolactone*},
  author={Y. -M. She and Keding Cheng and Aaron Farnsworth and Xuguang Li and Terry D. Cyr},
Inactivation of intact influenza viruses using formaldehyde or β-propiolactone (BPL) is essential for vaccine production and safety. The extent of chemical modifications of such reagents on viral proteins needs to be extensively investigated to better control the reactions and quality of vaccines. We have evaluated the effect of BPL inactivation on two candidate re-assortant vaccines (NIBRG-121xp and NYMC-X181A) derived from A/California/07/2009 pandemic influenza viruses using high-resolution… CONTINUE READING
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