Surface modification of nanoparticles by PEO/PPO block copolymers to minimize interactions with blood components and prolong blood circulation in rats.

@article{Tan1993SurfaceMO,
  title={Surface modification of nanoparticles by PEO/PPO block copolymers to minimize interactions with blood components and prolong blood circulation in rats.},
  author={Jack S. Eddy Tan and David Butterfield and C L Voycheck and Karin D. Caldwell and Jian-Hong Li},
  journal={Biomaterials},
  year={1993},
  volume={14 11},
  pages={823-33}
}
The biological fate of injected foreign particles is believed to be closely related to their interactions with blood plasma proteins and cells. In order to verify this correlation, we have quantitatively measured protein adsorption and blood retention profiles in rats by using model polystyrene latex nanoparticles. The in vitro interactions of these non… CONTINUE READING