Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats.

@article{Sakai1997SurfaceMO,
  title={Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats.},
  author={Hiromi Sakai and Shinji Takeoka and Steven I. Park and Tomohiro Kose and Hiroyuki Nishide and Yuishin Izumi and Akira Yoshizu and Kouichi Wako Kobayashi and Eishun Tsuchida},
  journal={Bioconjugate chemistry},
  year={1997},
  volume={8 1},
  pages={
          23-30
        }
}
Poly(ethylene glycol) (PEG5000)-conjugated phosphatidylethanolamine was introduced onto the surface of hemoglobin vesicles (HbV); phospholipid vesicles encapsulating concentrated Hb (d = 0.257 +/- 0.087 micron; P50 = 32 Torr). The obtained PEG-modified HbV (HbV-PEG) was studied for use as a red cell substitute from the viewpoint of rheology, surface properties, and hemodynamics. The viscosity of the unmodified HbV suspended in saline ([Hb] = 10 g/dL) was 2.6 cP (shear rate = 358 s-1, 37 degrees… CONTINUE READING
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