Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting.

@article{Fahmy2005SurfaceMO,
  title={Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting.},
  author={Tarek M. Fahmy and Robert M Samstein and Casey C Harness and W. Mark Saltzman},
  journal={Biomaterials},
  year={2005},
  volume={26 28},
  pages={5727-36}
}
We describe a general method for incorporating target ligands into the surface of biocompatible polyester poly(lactic-co-glycolic acid) (PLGA) 50/50 materials using fatty acids. Avidin-fatty acid conjugates were prepared and efficiently incorporated into PLGA. Avidin was chosen as an adaptor protein to facilitate the attachment of a variety of biotinylated ligands. We show that fatty acid preferentially associates with the hydrophobic PLGA matrix, rather than the external aqueous environment… CONTINUE READING

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References

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Showing 1-10 of 33 references

Biodegrad - able microspheres with enhanced capacity for covalently bound surface ligands

ME Keegan, JL Falcone, TC Leung, WM Saltzman
Macromolecules • 2004

Biodegradable microspheres with enhanced capacity for covalently bound surface ligands. Macromolecules 2004;37:9779–84

ME Keegan, JL Falcone, TC Leung, WM. Saltzman
2004
View 1 Excerpt

A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.

Journal of controlled release : official journal of the Controlled Release Society • 2003
View 1 Excerpt

Artificial polymeric cells for targeted drug delivery.

Journal of controlled release : official journal of the Controlled Release Society • 2003
View 1 Excerpt

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