Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents.

@article{Ratzinger2010SurfaceMO,
  title={Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents.},
  author={Gerda Ratzinger and Prashant R Agrawal and Wilfried K{\"o}rner and Julia Lonkai and H. M. Sanders and Enzo Terreno and M. Ruzhansky-J. Wirth and Gustav J. Strijkers and Klaas Nicolay and Franz Gabor},
  journal={Biomaterials},
  year={2010},
  volume={31 33},
  pages={8716-23}
}
The preparation of particulate contrast agents for magnetic resonance imaging (MRI) based on biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanocarriers is reported. By spacer-aided covalent surface-grafting of the prominent chelating ligands diethylenetriaminepentaacetic acid (DTPA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA… CONTINUE READING