Surface membrane antigen expression changes induced in vitro by exogenous growth factors in chronic lymphocytic leukemia cells

@article{Vilpo2002SurfaceMA,
  title={Surface membrane antigen expression changes induced in vitro by exogenous growth factors in chronic lymphocytic leukemia cells},
  author={Juhani A. Vilpo and Janne Hulkkonen and Mikko A. Hurme and Leena Vilpo},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={1691-1698}
}
The factors determining the growth and survival of cells in B chronic lymphocytic leukemia (CLL) have remained poorly understood. We investigated the effects of optimal mitogen combinations (OMCs) on the expression of 26 surface membrane antigens among 33 CLL patients. The seven OMCs used were selected after pre-testing 14 combinations of (1) S. aureus Cowan I (SAC), (2) interleukin-2 (IL-2), (3) tumor necrosis factor alpha (TNF-α) and (4) 12-O-tetradecanoylphorbol 13-acetate (TPA; also known… CONTINUE READING

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