Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action

Abstract

The alarming increase of pathogenic bacteria that are resistant to multiple antibiotics is now recognized as a major health issue fuelling demand for new drugs. Bacterial resistance is often caused by molecular changes at the bacterial surface, which alter the nature of specific drug-target interactions. Here, we identify a novel mechanism by which drug… (More)
DOI: 10.1038/srep41206

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