Surface markers on human b and t lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations

@article{Jondal1975SurfaceMO,
  title={Surface markers on human b and t lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations},
  author={M. Jondal and H. Pross},
  journal={International Journal of Cancer},
  year={1975},
  volume={15}
}
The spontaneous lymphocyte‐mediated cytotoxicity (SLMC) of cells from normal donors against 19 different established cell lines was analysed. All normal lymphocytes were cytotoxic in all combinations tested in a 17 h 51Cr release assay. SLMC was found to be mediated by a minor subpopulation of lymphocytes with Fc/C3 receptors. Noncytotoxic SRBC binding T‐lymphocytes could be induced to become cytotoxic by the addition of Con A to the incubation medium. SLMC and lectin‐induced cytotoxicity were… Expand
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