Surface map comparison: studying function diversity of homologous proteins.

@article{Pawlowski2001SurfaceMC,
  title={Surface map comparison: studying function diversity of homologous proteins.},
  author={Krzysztof Pawlowski and Adam Godzik},
  journal={Journal of molecular biology},
  year={2001},
  volume={309 3},
  pages={793-806}
}
A simplified protein surface cartography approach has been developed to assist in the analysis of surface features in homologous families, and thus to predict conservation or divergence of protein functions and protein-protein interaction patterns. A spherical approximation of protein surface was used, with a focus on charged and hydrophobic residues. The resulting surface map allows for qualitative analysis and comparison of surfaces of proteins, but can also be used to define a simple… CONTINUE READING

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