Surface-induced aggregation of beta amyloid peptide by co-substituted alkanethiol monolayers supported on gold.

@article{McMasters2005SurfaceinducedAO,
  title={Surface-induced aggregation of beta amyloid peptide by co-substituted alkanethiol monolayers supported on gold.},
  author={Mariah J McMasters and Robert P. Hammer and Robin L McCarley},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2005},
  volume={21 10},
  pages={4464-70}
}
The primary pathological characteristic of Alzheimer's disease is the presence in the brain of self-assembled beta amyloid (Abeta) protein fibrils, consisting of 35-43 amino acid residues. The toxicity of the aggregated protein structures has previously been proposed to be related to the interaction of Abeta fibrils with neuronal membranes (phospholipid bilayers). Here, surfaces consisting of self-assembled alkanethiol monolayers with different end groups--supported on Au--are used to test the… CONTINUE READING

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