Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization.

@article{Azemi2008SurfaceIO,
  title={Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization.},
  author={Erdrin Azemi and William R Stauffer and Mark S Gostock and Carl F. Lagenaur and Xinyan Tracy Cui},
  journal={Acta biomaterialia},
  year={2008},
  volume={4 5},
  pages={
          1208-17
        }
}
Silicon-based implantable neural electrode arrays are known to experience failure during long-term recording, partially due to host tissue responses. Surface modification and immobilization of biomolecules may provide a means to improve their biocompatibility and integration within the host brain tissue. Previously, the laminin biomolecule or laminin fragments have been used to modify the neural probe's silicon surface to promote neuronal attachment and growth. Here we report the successful… CONTINUE READING
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